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Pak H Chan Selected Research

Superoxide Dismutase

2/2013Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice.
11/2012Interleukin 6-preconditioned neural stem cells reduce ischaemic injury in stroke mice.
4/2012Release of mitochondrial apoptogenic factors and cell death are mediated by CK2 and NADPH oxidase.
12/2011Neuroprotection by interleukin-6 is mediated by signal transducer and activator of transcription 3 and antioxidative signaling in ischemic stroke.
4/2011Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection.
6/2010Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection.
1/2010Mitochondrial and apoptotic neuronal death signaling pathways in cerebral ischemia.
7/2009Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion.
5/2009Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemia.
5/2009Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival.
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Pak H Chan Research Topics

Disease

55Brain Ischemia (Cerebral Ischemia)
02/2013 - 01/2002
32Ischemia
01/2014 - 01/2002
19Stroke (Strokes)
02/2013 - 01/2002
17Infarction (Infarctions)
01/2014 - 03/2002
16Brain Injuries (Brain Injury)
05/2012 - 03/2002
14Reperfusion Injury
01/2015 - 03/2002
10Hypoxia (Hypoxemia)
12/2016 - 10/2002
10Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
11/2012 - 04/2002
8Ischemic Stroke
01/2014 - 04/2006
5Edema (Dropsy)
10/2008 - 08/2002
4Cerebral Hemorrhage
12/2016 - 09/2008
4Inflammation (Inflammations)
06/2011 - 06/2006
4Brain Edema (Cerebral Edema)
12/2010 - 04/2002
3Transient Ischemic Attack
01/2013 - 05/2003
3Brain Infarction
06/2011 - 07/2009
3Mitochondrial Diseases (Mitochondrial Disease)
04/2011 - 05/2005
3Hemorrhage
06/2010 - 06/2006
3Hypoglycemia (Reactive Hypoglycemia)
10/2008 - 06/2003
3Spinal Cord Injuries (Spinal Cord Injury)
01/2008 - 12/2002
3Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
05/2006 - 08/2002
3Hypothermia
10/2002 - 01/2002
2Thrombosis (Thrombus)
01/2014 - 01/2013
2Intracranial Hemorrhages (Intracranial Hemorrhage)
06/2010 - 06/2006
2Heart Arrest (Cardiac Arrest)
07/2009 - 10/2008
2Central Nervous System Diseases (CNS Diseases)
10/2008 - 08/2002
2Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
05/2007 - 08/2006
2Hyperglycemia
03/2007 - 05/2002
1Hemorrhagic Stroke
12/2016

Drug/Important Bio-Agent (IBA)

37Superoxide DismutaseIBA
02/2013 - 01/2002
24ZincIBA
02/2013 - 01/2002
22CopperIBA
02/2013 - 01/2002
21Reactive Oxygen Species (Oxygen Radicals)IBA
09/2012 - 12/2002
16Superoxides (Superoxide)IBA
09/2012 - 01/2002
11Proteins (Proteins, Gene)FDA Link
05/2012 - 10/2003
10AntioxidantsIBA
01/2014 - 08/2002
10Cytochromes c (Cytochrome c)IBA
04/2012 - 01/2002
8Neuroprotective AgentsIBA
02/2013 - 10/2002
7NADPH Oxidases (NAD(P)H oxidase)IBA
04/2012 - 04/2007
6Oxygen (Dioxygen)IBA
01/2015 - 01/2002
6Matrix Metalloproteinases (MMPs)IBA
06/2010 - 09/2003
5Glucose (Dextrose)FDA LinkGeneric
01/2015 - 04/2005
5Superoxide Dismutase-1IBA
09/2012 - 12/2002
5Messenger RNA (mRNA)IBA
05/2012 - 08/2002
5NF-kappa B (NF-kB)IBA
12/2008 - 06/2005
5Phosphotransferases (Kinase)IBA
06/2005 - 01/2003
4DNA (Deoxyribonucleic Acid)IBA
02/2013 - 10/2003
4CytokinesIBA
11/2012 - 10/2005
4EnzymesIBA
11/2012 - 01/2005
4AnionsIBA
09/2012 - 10/2002
4Proline (L-Proline)FDA Link
01/2008 - 02/2004
4Matrix Metalloproteinase 9 (Gelatinase B)IBA
03/2007 - 05/2002
4eIF-2 Kinase (eIF 2 Kinase)IBA
06/2005 - 08/2003
4LipidsIBA
01/2005 - 10/2003
3STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
11/2012 - 05/2009
34- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA
06/2011 - 07/2009
3Free RadicalsIBA
04/2011 - 01/2002
3acetovanillone (apocynin)IBA
11/2009 - 04/2007
3Glycogen Synthase Kinase 3 betaIBA
05/2007 - 08/2006
3Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
12/2006 - 11/2004
3Peptide Initiation Factors (Initiation Factor)IBA
06/2005 - 08/2003
3CaspasesIBA
06/2004 - 01/2002
3Adenosine Triphosphate (ATP)IBA
04/2004 - 10/2002
3Caspase 9IBA
09/2003 - 01/2002
3Caspase 3 (Caspase-3)IBA
06/2003 - 01/2002
2Hemoglobins (Hemoglobin)IBA
12/2016 - 12/2010
2Tissue Plasminogen Activator (Alteplase)FDA Link
01/2014 - 09/2008
2Inhibitor of Apoptosis ProteinsIBA
11/2013 - 06/2004
2Interleukin-6 (Interleukin 6)IBA
11/2012 - 12/2011
2Mitogen-Activated Protein KinasesIBA
09/2012 - 03/2003
2CalciumIBA
05/2012 - 06/2003
28-Hydroxy-2'-DeoxyguanosineIBA
04/2012 - 07/2009
2Nitric Oxide (Nitrogen Monoxide)FDA Link
06/2011 - 10/2008
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2011 - 05/2002
2Oxidants (Oxidizing Agents)IBA
04/2011 - 10/2003
2I-kappa B KinaseIBA
07/2010 - 10/2005
2Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA
07/2009 - 05/2002
2p38 Mitogen-Activated Protein KinasesIBA
10/2008 - 03/2003
2Insulin (Novolin)FDA Link
04/2007 - 06/2003
2hydroethidineIBA
03/2007 - 03/2002
2Proteasome Endopeptidase Complex (Proteasome)IBA
05/2006 - 02/2005
2ErythropoietinFDA Link
03/2006 - 06/2005
2Apoptosis Inducing FactorIBA
12/2005 - 06/2003
2Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
11/2005 - 01/2003
2Complementary DNA (cDNA)IBA
10/2005 - 02/2003
2Nerve Growth Factor (NGF)IBA
07/2005 - 02/2004
2DNA Nucleotidylexotransferase (Terminal Deoxynucleotidyl Transferase)IBA
06/2005 - 05/2003
2Nucleic AcidsIBA
01/2005 - 01/2004
2Endoplasmic Reticulum Chaperone BiPIBA
10/2003 - 08/2003
2N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
07/2003 - 03/2003
2N-Methylaspartate (NMDA)IBA
07/2003 - 03/2003
2Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA
05/2003 - 11/2002
2KetamineFDA LinkGeneric
11/2002 - 04/2002
2Niacinamide (Nicotinamide)FDA LinkGeneric
11/2002 - 04/2002
1Therapeutic UsesIBA
12/2016

Therapy/Procedure

9Therapeutics
12/2016 - 06/2006
5Transplantation
12/2016 - 03/2012
2Stents
01/2013 - 08/2011
2Cell Transplantation
11/2012 - 09/2012
2Injections
12/2011 - 04/2006
2Sutures (Suture)
06/2003 - 03/2002